Effect of Etanercept Combined with Synovectomy on Function and Serum Levels of Associated Factors in AS Patients with Coexisting Coxarthrosis

Abstract

Objective To investigate the clinical effect and value of etanercept combined with arthroscopic synovectomy in the treatment of ankylosing spondylitis (AS) complicated with coxarthrosis. Methods 66 patients with AS complicated with coxarthrosis admitted in our hospital were taken as the study objects and were randomly divided into two groups with random number table: test group (n = 33) and control group (n = 33). The arthroscopic synovectomy was given to both groups. The control group was given basic anti-inflammatory and analgesic measures, promoting blood circulation and detumescent measures after surgery, and the test group was added with etanercept on the basis of the control group. Changes in scores of coxae function, serum transforming growth factor-β1 (TGF-β1), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) at different time after operation were compared between the two groups. Results There was no significant difference in Harris score between the test group and the control group before operation (P>0.05). The Harris score of the test group was higher than that of the control group 3 months after operation and 6 months after operation (P<0.05). There was no statistically significant difference in the determination of flexion angle and abduction angle of coxae between the test group and the control group before operation (P>0.05). The flexion angle and abduction angle of coxae of the test group were higher than that of the control group 6 months after operation (P<0.05). The difference of measured values of serum levels TGF-β1, TNF-α, IL-6, CRP and ESR in the test group and the control group had no statistical significance (P>0.05). The determination values of serum levels TGF-β1, TNF-α, IL-6, CRP and ESR in the test group were lower than those in the control group at 3 months after operation (P<0.05). Conclusion Etanercept combined with arthroscopic synovectomy for the treatment of AS complicated with coxarthrosis is beneficial to regulate the level of related cytokines and promote the recovery of postoperative joint function.