Analysis of the Protective Effect of Interleukin-5 On Sepsis Mice

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Xiaokun Wang, Fuyang Pei, Xiaoping Song, Hongmei Wang

Abstract

IL-5 can stimulate the growth and differentiation of EOS, inhibit its apoptosis and stimulate the proliferation and differentiation of B cells with other cytokines, and act on mature B cells to promote the synthesis of IgA and IgM. Therefore, this paper takes C57BL / 6 mice as the experimental object to explore the protective effect of interleukin-5 on sepsis mice. The experimental results show that the serum cxcl-1 in sepsis model group is significantly higher than that in control group at each time point, reaching the peak at 12 h, while cxcl-1 in IL-5 intervention group is significantly lower than that in control group. IL-5 can reverse the liver injury induced by CLP in septic mice, the mechanism may be to reduce the production of inflammatory factors in the liver, and the liver function of mice was not damaged 12 hours after sepsis. IL-4 and IL-13 of type 2 inflammatory response factors can promote the conversion of macrophages to anti-inflammatory macrophages, inhibit the inflammatory reaction, and play a protective role in sepsis.

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