The Effectiveness of Urokinase and Vitamin C in the Treatment of Arterial Occlusion Caused by Agarose Gel Injection

Abstract

Background and Aim: The agarose gel, which is a new generation of dermal filler, provides a great option for  non-surgical aesthetic procedures. In this study it was aimed to determine the effectiveness of vitamin C and/or thrombolytic therapy in the complications that cause intraarterial occlusion of agarose gel.

Matarials and Methods: This study was carried out with a total of 36 adult male Wistar rats. Rats using defined flap model were divided into 4 groups as 3 experimental and 1 control. Agarose gel 1.5%, was injected into the left inferior epigastric artery from its bifurcation with the femoral artery and occlusion was achieved.A different drug was given to each group who underwent occlusion of the artery, and the drugs were injected intravenously through the tail vein 45 minutes after the artery blockage. Vitamin C and urokinase were injected into rats in Group A; Vitamin C was injected into Group B; Urokinase was injected into Group C and physiological serum was injected into Group D. Photographic measurements were made on the flaps and the necrotized and survived areas were statistically examined.

Results: It was found out that both the combination of Vitamin C and Urokinase and only Urokinase treatment significantly increased flap survival  in the treatment of arterial agarose gel occlusion.

Conclusion: According to the results of the study it was concluded that the use of only urokinase was as effective as a combination of vitamin C and urokinase. The thrombolytic therapy alone could be  effective for the treatment of arterial vascular occlusions caused by agarose gel.