Serum Galectin-3 and Poor Functional Outcome in Acute Ischemic Stroke

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Aliaa Mohamed Abd El Khalik Ahmed et al.

Abstract

Objective: The current study aimed to investigate the role of serum Galectin-3 level as a prognosticator of short-term outcome in acute ischemic stroke (AIS). Patient and methods: Ninety cases with former acute ischemic stroke (36 males and 54females)were presented in this prospective cohort study. Stroke severity was assessed on admission by the National Institutes of Health Stroke Scale (NIHSS), and functional results were evaluated after 12 weeks of admission by Modified Rankin Scale (mRs). Galectin-3 levels were assessed using the ELISA technique.


Results: The results revealed that the association between Galectin-3 level and diabetes mellitus, hypertension, obesity, cardiac diseases, stroke severity, and poor functional outcome were significantly different. The relation regarding Galectin-3 levels and the size of the infarction showed a significant positive correlation. Binary logistic regression analysis of neurological outcome with associated risk factors demonstrated that diabetes mellitus, elevated serum Galectin-3 level, NIHSS, and mRS scores were the most significant risk factors for predicting deterioration and short-term outcome after ischemic stroke after adjustment of other confounding variables.

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