Assessment of Gut Microbiome, their Relationship to Severity and Response to Treatment in Ulcerative Colitis patients

Abstract

Background: intestinal microflora plays an important role in health and disease and it plays a great role in ulcerative colitis patients.

Patients and methods: Acase control followed by cohort study carried out in Internal Medicine Department, and Immunology Departments, Faculty of Medicine, Zagazig university hospitals. All subjects submitted to full history taking, clinical examination, colonscopy and laboratory Investigations. Assessment of fecal microbes was done.

Results:. There is significant increase in lactobacilli or vionella after treatment in those with remission while there is non-significant increase in relapse. There is statistically non-significant relation between outcome and bacteroid before treatment however, there is significant difference between them after treatment (higher in remission). Within each group, there is significant decrease in bacteroid after treatment. There is statistically significant relation between severity after treatment and fecal, bacteroid and lactobacilli level after treatment.

Conclusion: fecal microbiome are highly specialized structure, diagnosis and monitor ulcerative colitis can be done based on fecal microbiome