Possible Relation between Exercise, Nonalcoholic Fatty Liver Disease and Adropin

Abstract

Background: Adropin is a peptide hormone which was discovered in 2008 by Kumar and his coworkers during the microarray analysis of liver gene expression in mouse models of obesity and insulin resistance, where it is a novel factor linking signals of nutrient intake with metabolic homeostasis. The increasing prevalence of obesity had lead to nonalcoholic fatty liver disease (NAFLD) “the most common chronic liver disease”. NAFLD is defined as the presence of hepatic steatosis in the absence of any other causes of chronic liver disease, alcohol consumption or treatment with steatogenic medications. NAFLD and especially its inflammatory form nonalcoholic steatohepatitis (NASH) are the most common cause of end-stage liver disease and hepatocellular carcinoma. Regular exercise can improve quality of life, cognitive function. Exercise can cause weight loss and plays an important role in weight management. A strong correlation between physical activity and non-communicable diseases including diabetes, metabolic syndrome, cardiovascular diseases and cancer.