Formulations and Evaluation of Green Tea Extract Based Lozenges for In-Vitro Anti-Cancer Activity

Abstract

Objectives:The goal of this study is to develop and test green tea extract lozenges for anticancer activity and medication delivery into the buccal cavity. It helps with oxidative and inflammatory disorders, metabolic syndrome, arthritis, anxiety, and hyperlipidemia treatment. Anticancer activity of green tea extract lozenges was investigated. The goal of this study is to develop and test green tea extract lozenges for anticancer activity and medication delivery into the buccal cavity. It helps with oxidative and inflammatory disorders, metabolic syndrome, arthritis, anxiety, and hyperlipidemia treatment. Anticancer activity of green tea extract lozenges was investigated.

Method: Solid dispersion of green tea extract was prepared using β-cyclodextrin to enhance the solubility of green tea extract. The prepared solid dispersion of green tea extract was analysed for solubility enhancement then formulated with the same, liquid glucose, sucrose and corn syrup by heat, and congealing technique. The prepared lozenges were evaluated for drug-excipient incompatibility study, colour, odour, taste and hardness.

Results: The results of the compatibility study showed that there was no interaction between the selected drug and excipients. In-vivo studies of the lozenges were optimized based on in in-vitro drug release, drug Stability studies revealed that the formulation was stable, green tea extract having greatest anticancer activity 46% towards prostate cancer cell, 4% towards liver cancer cell, lungs cancer cell 28% and average of 62% towards colon cancer cell compared to standard anticancer drugs like 5-Fu, Mito-C and Paclitaxel.

Conclusion: From the present work, it was concluded that the green tea extract’s lozenges can be considered as a suitable delivery system for the treatment variety of Cancer.