Immunological Aspects of Cutaneous Psoriasis: A Review

Abstract

Background: Psoriasis is a chronic, hyper proliferative inflammatory skin disease, which is clinically characterized by erythematous and squamous plaques. Psoriasis manifests in several ways: plaque, flexural, guttate, pustular and erythrodermic psoriasis. Overproliferation and aberrant differentiation of epidermal keratinocytes are the key features of psoriasis. Psoriasis is a multifactorial disease with multiple important components such as genetic susceptibility, environmental triggers along with immune dysfunction and skin barrier disruption. It is known to be a T-cell-mediated autoimmune skin disease.