The Crosslink between COX2 and Chemoresistance

Abstract

Background: Chemoresistance and tumour relapse remain major clinical problems. Accumulating evidence indicates that the COX2/PGE2/EP axis plays critical roles not only in tumor development including initiation and progression but also in the development of therapeutic resistance. Few studies evaluated the crosslink between COX-2, chemotherapy and chemoresistance.  In this review we will give an overview about the relation of the COX-2 gene expression with chemoresistance in colon cancer patients. Also, the effects of cytotoxic chemotherapy on COX-2 expression.