Evaluation of Prostatic Semeno Microprotein and CD68 Immunohistochemical Expression in Renal Allograft Rejection

Abstract

Rejection is considered the major obstacle to long-term allograft survival. Many studies suggest that macrophage recruitment plays an important role in the development of graft rejection and could express CD68 immunohistochemical marker. The persistent inflammation mediated by macrophages may lead to fibrosis and chronic rejection in renal allograft. PSMP is a newly identified protein which can bind to c-c motif chemokine receptor 2 (CCR2) leading to macrophage recruitment. In this study, 50 cases of renal allograft  rejection were collected from urology and nephrology center, Mansoura university to evaluate both PSMP and CD68 immunohistochemical expression. The present study showed statistically significant association between CD68 score and borderline TCMR cases (P<0.001) while PSMP score showed significant association with CABMR cases (P=0.004). Also, a high statistically significant positive correlation was found between PSMP and CD68 scores among studied patients (P =0.001). (r =0.51). PSMP was found to have an important role in renal allograft rejection so target therapy directed against PSMP could help to delay the process of rejection.