Protective Roles of Probiotics against Alzheimer’s Disease

Abstract

One of the leading causes of disability, death, and morbidity worldwide, Alzheimer's disease (AD) is a neurological disorder that worsens over time. There is an immediate and critical need to seek out fresh viewpoints due to the decades-long failure in medication discovery. Due to its strong associations with amyloids, systemic and focal inflammation, impairment of vascular homeostasis and gut barrier, mitochondrial dysfunction, etc., the gut microbiome (GM) has recently garnered a lot of attention in AD-related studies. The GM can communicate with the brain in both directions through the microbiome-gut-brain axis. As a result, probiotic supplementation, which regulates the GM, is a promising candidate for the treatment of AD. The goal of this article is to summarize the most recent findings on the efficacy of probiotics in the treatment and prevention of Alzheimer's disease, as well as the possible roles of genetic modification in the development of the disease.